objective:
@EN The purpose of this study is to investigate the effects of preischemic hyperglycemia on the alterations of adenosine triphosphate and lactate concentrations in the acute focal ischemic brain of the cats.
@ES Methods:
@EN Acute focal cerebral ischemia in cats was induced by occlusion of the left middle cerebral artery through the postorbital technique.
The experimental animals were divided into 3 groups: sham control, occlusion and recirculation groups.
Each group was divided into 2 subgroups: normoglycemic and hyperglycemic groups
@ES Results: The experimental results are obtained as follows:
@EN 1) In normoglycemic subgroups of occlusion and recirculation groups, amount of adenosine triphosphate in ischmic brain decreased significantly to 3.0% and 13.0% of the sham control, respectively(P<0.001).
In hyperglycemic subgroups of occlusion and recirculation groups, amount of adenosine trisphosphate decreased a little more than that in normoglycemic subgroups; even so there was no statistic significantly(P>0.1).
2) In normoglycemic subgroups of occlusion and recirculation groups, amount of lactate in ischemic brain increased significantly to 175.7% and 187.9% of the sham control, respectively(P<0.001).
In hyperglycemic subgroups of occlusion and recirculation groups, amount of lactate increased more than that in normoglycemic subgroups with statistic significancy(0.001@ES Conclusion:
@EN These results suggest that hyperglycemia before ischemia serves to elevate glucose transport into brain tissue and thereby, to promote profound tissue acidosis through anaerobic glycolysis caused by a failure of adenosine triphosphate
synthesis
during the ischemic period.
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